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JM

Jennifer

Provide a summary of Lilly's likely BD priorities based on their past few earnings calls?

MB

Maven

Sources:

Eli Lilly And Co (LLY) - Q1 2024 Earnings Call

Earnings Call Transcript

Answer:

Based on analysis of Eli Lilly and Company's recent earnings calls, the company's business development (BD) priorities can be summarized as follows:

1. Expansion Through Strategic Acquisitions

Lilly has demonstrated a clear focus on expanding its pipeline and capabilities through targeted acquisitions of clinical-stage companies and technologies. For instance, recent acquisitions include DICE Therapeutics, Versanis Bio, Emergence Therapeutics, Sigilon Therapeutics, and POINT Biopharma. These acquisitions are intended to bolster their Phase 2 portfolio and expand capabilities in areas like radioligand therapies and immuno-oncology [1].

2. Focus on Innovative Therapies for Key Therapeutic Areas

Lilly continues to prioritize treatment areas such as oncology, immunology, diabetes, and neuroscience: - Oncology: The acquisition of POINT Biopharma highlights their interest in next-generation radioligand therapies for cancer[2]. - Diabetes: Innovations in diabetes treatment remain a top priority, with investments in expanding capacities for therapies like Mounjaro (tirzepatide)[1]. - Neuroscience and Immunology: With the recent Phase 1/2 trial for the Otoferlin Gene therapy asset and completed Phase 3 trials for innovative drugs like mirikizumab, Lilly is clearly focused on advancing their offerings in these fields despite facing operational challenges such as manufacturing issues with lebrikizumab's third-party suppliers [1].

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Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells

2023-8-23

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Press Release

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Kite Pharma

PFS is defined as the time from the KITE-718 infusion date to the date of disease progression per modified RECIST v1.1 or consensus panel 1 criteria or death from any cause.

Aim Immunotech (AIM) - 8-K Filing Exhibit

2024-4-24

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8K

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Aim Immunotech

The presentation highlights the potential of Ampligen®, a dsRNA/TLR3 agonist, in modulating chemokines to enhance T effector cell infiltration in tumors, particularly in colorectal cancer. Data shows Ampligen's efficacy in improving Teff/Treg ratio across various solid tumors. A recent study in late-stage pancreatic cancer patients demonstrated a significant increase in overall survival with Ampligen monotherapy, leading to FDA clearance for a Phase 2 study. Ampligen also shows promise in ME/CFS and post-COVID chronic fatigue-like conditions. AIM ImmunoTech, the company behind Ampl

ImmunoBiochem Corp.

2024-4-02

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News Article

Continued Strong Demand for ELAHERE; US Net Sales of $105.2 Million in Q3 ELAHERE MAA in FRα-Positive Platinum-Resistant Ovarian Cancer Accepted by EMA; sBLA to Support Full Approval in US Submitted to FDA PICCOLO Trial of ELAHERE in Platinum-Sensitive Ovarian Cancer Meets Primary Endpoint of Objective Response Rate; Full Data Anticipated in Mid-2024 Advanced Geographic Market Expansion ...

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JM

Jennifer

Give an overview of Allogene. I have a meeting with them tomorrow.

MB

Maven

Sources:

Allogene Therapeutics S-1 Breakdown

SEC Filing

Answer:

Allogene Therapeutics is a clinical-stage biotechnology company that is pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer[1]. The company is headquartered in South San Francisco and is led by a management team with significant experience in cell therapy. Allogene is focused on developing a pipeline of "off-the-shelf" CAR T cell therapy candidates with the aim of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients[1].


The founders of Allogene, Arie Belldegrun and David Chang, previously sold their first CAR-T company, Kite Pharma, for $12 billion. Following the acquisition of Kite by Gilead, they founded Allogene with a focus on developing allogeneic CAR therapeutics[1]. The company was launched with a strategy to acquire and develop a portfolio of 16 preclinical cell therapy assets from Pfizer, including UCART19, an allogeneic CAR T therapy targeting CD19 currently in Phase 1 development for the treatment of refractory and relapsed acute lymphoblastic leukemia (ALL)[1][4]. This acquisition marked Pfizer’s exit from adoptive cell therapy, but allowed them to retain a 25 percent ownership stake in Allogene[4].


Allogene has made significant progress in its development pipeline, including the initiation of the Phase 1/2 ALPHA clinical trial of ALLO-501, an anti-CD19 AlloCAR T™ product in patients with relapsed/refractory non-Hodgkin lymphoma. The company has also been working on building a state-of-the-art AlloCAR T™ manufacturing facility in Newark, California, and has presented initial Phase 1 data for several of its therapies[4].


In terms of financial milestones, Allogene completed one of the largest Series A financing rounds in biotechnology history, raising $300 million. This was followed by a successful public company debut, raising $372.6 million in gross proceeds in what was the second-largest biotechnology IPO of 2018[4][4].

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